Bone mechanics from molecule to organ

Background: Computational models could be a cornerstone in digital healthcare to tackle the socioeconomic burden associated with bone-related diseases such as osteoporosis, osteoarthritis and bone cancer. This includes improved diagnoses, the manufacturing of custom implants and the monitoring of bone implant systems in personalised medicine. Such models strongly depend on understanding the complex characteristics of bone as a material on its different hierarchical levels. To address this, we need a comprehensive modelling framework that is able to simulate the nonlinear mechanical behaviour of bone tissue from the molecular up to the macroscopic length scale.

Project: Therefore, this project aims at developing a computational framework to model of bone tissue. This development will be based on an existing micromechanical models. Key tasks are

  1. use molecular dynamics to simulate stiffness and strength of the mineral phase in bone
  2. combine these results with an existing micromechanical model of bone
  3. use this multiscale model to compute stresses and strains in the human hip.

Impact: If successful, the models will help to improve understanding bone failure with respect to ageing and disease. In addition, the results will inform the development of advanced implant materials.

Other Comments: 

some programming skills needed

Supervisor name: 
Uwe Wolfram and Ali Ozel
Supervisor and Deputy email addresses: 
u.wolfram@hw.ac.uk, a.ozel@hw.ac.uk
Project location: 
Project is computational so that remote supervision is possible