Bone micromechanics

Background: Musculoskeletal diseases affect millions of people in ageing societies world wide. Osteoporosis, for instance, is characterised by decreasing structural integrity and mechanical competence of bones which leads to an increase in fracture incidence and mortality. Despite decades of research, patient specific implant techniques are still not available. Computational models that include the mechanical behaviour of mineralised collagen fibres, bones fundamental building block, could help to create personalised implants. However, currently no such model is existing.

Project: Therefore, this project aims at developing a computational micromechanical model of bone tissue. This development will be based on an existing theoretical model. Key tasks are

(i) implement the existing theoretical model in, e.g., Abaqus,
(ii) verify its usability against existing experimental results, and
(iii) use that model to compute stresses in the extra-cellular matrix.

Impact: If successful, the models will help to improve understanding bone failure with respect to ageing and disease. In addition, the results will inform the development of advanced implant materials.

Supervisor name: 
Uwe Wolfram
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