Development of “Cheap” Digital Holographic Microscope

Nanotechnology has the potential to make a significant impact on healthcare and recently offers multiple benefits in treating human diseases by target-oriented precise drug delivery. Applications of target-oriented drug delivery intend to reduce the side effects associated to the indiscriminate use of drug and treatment costs. Targeting is possible by engineering surface of nanoparticles whose typical sizes are in the range of 1 to 1000nm. The key questions regarding the targeting are how nanoparticles and cell membranes interact at a single-cell level and across a tissue. Most of experimental studies have been focused on the exposure of nanoparticles with high concentration to tissue from a medical perspective. Recently, at a single-cell level, the computer-aided simulations have been utilised to provide detail information of cellular uptake mechanism. However, these simulations cannot use at tissue scale due to being computationally prohibitive. In this project, we will construct a new experimental technique, namely “cheap” digital holographic microscope and develop mathematical modelling framework that enables analysis of multi- body particle-cell membrane interaction from the meso-scale (~100-1000 nanometres) to a tissue scale. This framework will fill the gap between existing single-cell level computational and experimental exposure concentration studies.

Supervisor name: 
Dr. Ali Ozel
Supervisor and Deputy email addresses: 
a.ozel@hw.ac.uk