EPS PGR Annual Christmas Lecture 2019: "150 Years of the Periodic Table: The Elements of Life and Medicines"
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EPS PGR Annual Christmas Lecture 2019: "150 Years of the Periodic Table: The Elements of Life and Medicines"
Thu, 12/12/2019 - 14:00
Location:
Speaker:
Prof. Peter Sadler
Affiliation:
University of Warwick
Synopsis:
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Over the last 150 years, Mendeleev’s periodic table of 63 elements has expanded to 118. Although the chemistry of most of the elements is now well explored, their biological roles are not well defined. I will make an element-by-element journey through the periodic table, identify the 19 elements which are essential for human life, the 7 which may be, as well as the 76 stable and radioactive elements in clinical use, or in clinical trials, as medicines and diagnostic agents, and highlight gaps in our knowledge. I will describe our recent attempts to design anticancer and antimicrobial drugs with novel mechanisms of action to combat resistance to treatment. These include photoactivatable and organometallic precious metal catalysts.
References
Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design
J.J. Soldevila-Barreda, I. Romero-Canelón, A. Habtemariam, P.J. Sadler
Nature Commun. 2015, 6:6582.
Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells
J.P.C. Coverdale, I. Romero-Canelón, C. Sanchez-Cano, G.J. Clarkson, A. Habtemariam, M. Wills, P.J. Sadler
Nature Chem. 2018, 10, 347-354.
Targeted photoredox catalysis in cancer cells
H. Huang, S. Banerjee, K. Qiu, P. Zhang, O. Blacque, T. Malcomson, M.J. Paterson, G.J. Clarkson, M. Staniforth, V.G. Stavros, G. Gasser, H. Chao, P.J. Sadler
Nature Chem. 2019, in press (DOI : 10.1038/s41557-019-0328-4).
Biography:
Peter Sadler obtained his BA, MA and DPhil at the University of Oxford. Subsequently he was a Medical Research Council Research Fellow at the University of Cambridge and National Institute for Medical Research. From 1973-96 he was Lecturer, Reader and Professor at Birkbeck College, University of London, and from 1996-2007 Crum Brown Chair of Chemistry at the University of Edinburgh, Director of the Edinburgh Protein Interaction Centre and EastChem Cancer Research UK Cancer Medicinal Chemistry Centre. In June 2007 he took up a Chair in Chemistry at the University of Warwick as Head of Department, where he is now a Professor.
He is a Fellow of the Royal Society of Edinburgh (FRSE) and the Royal Society of London (FRS), and EPSRC RISE Fellow (Recognising Inspirational Scientists and Engineers).