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The development of van der Waals structures made by stacking two-dimensional (2D) crystals has led to the discovery of physical phenomena of fundamental and technological interest. This seminar will review my research at Nottingham on a new class of 2D metal chalcogenide layered compounds suitable for versatile band-gap engineering. From the growth and fabrication of new structures to the demonstration of prototype devices, I will discuss how these layers can provide a platform for scientific investigations and new routes to 2D electronics and optoelectronics.