Breaking anchors to boost cyclic AMP signalling.
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Breaking anchors to boost cyclic AMP signalling.
Wed, 08/05/2019 - 13:30 to 14:30
Location:
Speaker:
George Baillie
Affiliation:
University of Glasgow
Synopsis:
Phosphodiesterase are the only class of enzymes that can degrade cAMP and hence terminate cAMP signalling following activation of Gs-coupled receptors. As there are 4 different classes of proteins that can be activated by cAMP, PDEs are often found in protein complexes with cAMP effectors to prevent inappropriate activation in times of basal Adenylate cyclase activity. In light of this, pharmacological PDE inhibitors are often not suitable for the clinic as they concomitantly attenuate activity of many PDE isoforms in a variety of cellular locations. I will introduce the concept of targeting PDE location rather than activity as a therapeutic target and will describe how the art of protein-protein disruption has been used by my lab in a number of disease areas (some not involving PDEs!).
Biography:
GSB is a Professor and PI within the Institute of Cardiovascular and Medical Sciences and Dean of Graduate Studies at the University of Glasgow. His research over the last 15 years has examined many aspects of the cAMP signalling pathway in disease and he has published over 180 papers on the subject. GSB is a specialist in the use of peptide array technology and uses it to map regions of post-translational modification, protein-protein interaction sites and define the antigen specificity of antibodies. GBS's major discovery was that phosphodiesterases are “compartmentalized”, and it is their location within cells that direct their function. His lab was the first to discover a specific function for a single isoform of PDE4 (namely PDE4D5 with beta-arrestin desensitizes the beta2-adrenergic receptor) and this was published in Science. GSB's lab has since gone on to ascribe functions to several other PDE4 isoforms and these discoveries have been published in Science, Nature, PNAS, EMBO, Molecular Cell and Current Biology. GSB is also the founder and director of Portage Glasgow Ltd, a spin-out venture within Glasgow University and Editor-in-Chief of Cellular Signalling Journal.
History
2007 – Present Professor/group leader/PI , Institute of Cardiovascular and Medical Sciences, Wolfson Building, Glasgow University
2016-present Dean of Graduate Studies, College of Medical, Veterinary and Life Sciences, University of Glasgow
1998 – 2007 Senior research assistant (RA II) and Lab Manager, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, UK.
1995 – 1998 Postdoctoral Research Assistant, Division of Infection and Immunity, University of Glasgow, Glasgow, UK
1993 – 1995 Postdoctoral Research Assistant, Pharmaceutical Sciences Department, Strathclyde University, Glasgow.
1992 - 1993 Biochemistry Teacher within Biochemistry and Life Sciences Department, University of London, Royal Holloway College, Egham, Surrey, UK.
1989-1992 CASE award PhD in Biochemistry at University of Kent, Canterbury, UK in conjunction with Pfizer.