Building implantable human liver tissue from pluripotent stem cells


Building implantable human liver tissue from pluripotent stem cells

Wed, 23/11/2022 - 13:30 to 14:30


David Hay
University of Edinburgh

Talk content:

- Somatic cell differentiation from pluripotent stem cells
- Liver tissue engineering taking advantage of cell self-assembly
- Liver sphere modelling of fatty liver disease, drug toxicity, and cancer
- Development of a sub-cutaneous liver implant to support failing liver function
- Process automation, scale-up, and technology translation


Dave is the Professor of Tissue Engineering at the University of Edinburgh. He gained his PhD from the University of St Andrews in 2000. Following this, he undertook post-doctoral projects at Roslin Institute and the University of Edinburgh, before starting his group at the Centre for Regenerative Medicine in 2008. Dave has worked in the field of stem cell biology and differentiation for over 20 years. He and his team have highlighted the important role that pluripotent stem cells have to play in modelling human liver biology ‘in the dish’ and supporting failing liver function in vivo. The impact of this work has led to a number of peer-reviewed publications (>100) and regular appearances at high profile conferences.