Flow chemistry as enabling technology for exploring new chemical space and developing sustainable synthetic tactics

Flow chemistry can be seen as a technology that enables the creation of sustainable synthetic processes and the exploration of new chemical territory. It also offers precise control over reaction parameters, enabling the use of highly reactive and unstable intermediates.[1] In this discussion, the chemistry of organolithiums, halocarbenoids, strained heterocycles, and overlooked sulfur functional groups will be explored along with the crucial role of flow technology and flash chemistry in developing synthetic strategies. The superiority of flow technology compared to batch processing will be a major focus. [2-5]

References
[1] Colella, M.; Nagaki, A.; Luisi, R. Chem. Eur. J. 2019, 26, 19–32.
[2] Musci, P.; Keutz, T.; Belaj, F.; Degennaro, L.; Cantillo, D.; Kappe, C. O.; Luisi, R. Angew. Chem. Int. Ed. 2021, 133, 6465–6469.
[3] Musci, P.; Colella, M.; Sivo, A.; Romanazzi, G.; Luisi, R.; Degennaro, L. Org. Lett. 2020, 22, 3623–3627.
[4] Colella, M.; Tota, A.; Takahashi, Y.; Higuma, R.; Ishikawa, S.; Degennaro, L.; Luisi, R.; Nagaki, A. Angew. Chem. Int. Ed. 2020, 132, 11016–11020.
[5] Andresini, M.; Tota, A.; Degennaro, L.; Bull, J. A.; Luisi, R. Chem. Eur. J. 2021, 27, 17293–17321.