Towards Automating the Enrichment of Circulating Tumour DNA

Circulating tumour DNA (ctDNA) holds great promise for non-invasive cancer diagnostics, yet its low abundance remains a key challenge. In this seminar I will introduce two nuclease-based enrichment strategies and my initial work to automate them. By integrating these assays into a liquid handling system, I aim to enhance the efficiency, reproducibility, and scalability of ctDNA analysis. Preliminary automation results and future directions will be discussed.