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The synergistic integration of photonic and fluidic components in microfluidics, offers the possibility to create alignment-‐free devices with novel functionalities and enhanced sensing capability. Within the domain of photofluidics, direct laser writing (DLW) has emerged as a powerful microfabrication tool driven by its distinctive multifaceted potential to create low-‐loss, three-‐dimensional optical waveguides as well as chemically etched, high aspect ratio, buried microfluidic channels over a wide choice of substrate materials. This allows the formation of highly stable, monolithic Lab-‐on-‐Chip environments offering significant improvements in both sensitivity and selectivity. This talk will summarise some of the recent developments in DLW enabled biochips showing results that underscore the unique advantages offered by DLW in generating future photofluidic applications.