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This talk will discuss about the development of a variety of microengineered tools to investigate the interactions in biological systems. The fundamental principle of the microtools is to detect the “stress” generated by biology and to manipulate biology through “pressure”. The talk will cover the examples of how we can detect DNA, protein and cells using stress biosensors, to probe tissue quality through a pneumatic actuated sensor, to assemble genes using a pneumatically driven microfluidic chip and to build a mini-organ through a pneumatically driven bioprinter.