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Modern medical imaging has revolutionalised diagnoses and treatment and is rapidly advancing our understanding of brain and body structure, function and changes in disease. This seminar will briefly summarise the medical imaging technologies available to researchers in Edinburgh. Then, use examples from brain imaging to show how our understanding of common disorders is being transformed by different magnetic resonance brain imaging techniques. In the process, highlight the major challenges for image analysis to extract subtle biological information from complex image data and opportunities for multidisciplinary efforts to overcome these challenges.