Cell-free circulating histones come of age as liquid biopsies
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Cell-free circulating histones come of age as liquid biopsies
Wed, 26/05/2021 - 13:30 to 14:30
Location:
Speaker:
Manlio Vinciguerra
Affiliation:
St. Anne's University Hospital, Pekařská, BRNO
Synopsis:
A liquid biopsy is the sampling and analysis of non-solid biological tissue, primarily blood but also cerebrospinal fluid. Like traditional biopsies, liquid biopsy is mainly used as a diagnostic and monitoring tool for diseases such as cancer, with the added benefit of being non-invasive. Therefore, it can also be done more frequently which can better track tumors, mutations, the efficiency of cancer treatment over time, and relapse. So far, liquid biopsy is mostly restricted to cell free DNA, which displays limitations of quantity, integrity and reproducibility. As such, clinical implementation of liquid biopsies is not yet widespread but is becoming standard of care in some areas, like colorectal carcinoma. In this seminar, I will discuss the potential and robustness of alternative liquid biopsies, cell free circulating histones and histone complexes, in metabolic diseases and various malignancies, both in children and in adults. I will also present a comparative analysis of the available technologies to detect circulating histones, and future perspectives.
Biography:
Dr. Manlio Vinciguerra is currently (2016 - ) European Research Area (ERA) Chair and a Principal Investigator at the Center for Translational Medicine, International Clinical Research Center (ICRC), Brno, Czech Republic; and Honorary Senior Research Fellow - Institute for Liver and Digestive Health, University College London, UK.
Brief bio:
Principal Research Associate - University College London (UCL), London, UK 2012 - 2016
Post-doc - European Molecular Biology Laboratory (EMBL, Italy and Germany) 2008 - 2011
Post-doc - University of Geneva, Switzerland 2005 - 2008
PhD student - University of Geneva, Switzerland 2001 - 2004
BSc student - University of Catania, Italy 1994 – 1999
Dr. Vinciguerra has a wide range of interests, ranging from metabolism (liver diseases), epigenetics (histone variants), to aging (senolytics) and pre-clinical medicine in various organ systems. He authored about 190 publications with Impact Factor, between research papers, reviews, editorials and book chapters, receiving >7200 citations, H index = 46 (Google Scholar).
Representative publications: Vinciguerra M et al., Gastroenterology 2008: https://pubmed.ncbi.nlm.nih.gov/18166358/ Brandhorst S et al., Cell Metab 2015: https://pubmed.ncbi.nlm.nih.gov/26094889/ Borghesan M et al., Cancer Res 2016: https://pubmed.ncbi.nlm.nih.gov/26772755/ Lo Re O et al., Hepatology 2018: https://pubmed.ncbi.nlm.nih.gov/28913935/ Calimport S et al., Science 2019: https://pubmed.ncbi.nlm.nih.gov/31672885/ Lo Re O et al., Theranostics 2020: https://pubmed.ncbi.nlm.nih.gov/31903159/