Ferrocenyl moieties and their effects on the cytotoxicity of mammalian cells

It has been long known than the introduction of ferrocenyl moieties into organic compounds can improve their anticancer and antibacterial activities. The best-known example is the inclusion into the drug Tamoxifen, where the ferrocenyl (ferrocifen) moiety increases the cytotoxicity and the selectivity of the drug towards the treatment of aggressive triple negative breast cancers. This seminar will highlighted how we have used ferrocenyl beta-diketonate ligands to form bimetallic complexes with both precious metals or biorelevant metals, and we show their ability to induce nanomolar cell potency, increase cell death and promote genomic DNA interactions.