A Total Photon camera for molecular imaging of live cells.

The project aims to develop several super-fast cameras for super-resolution microscopy. Along side testing and implementing the camera technologies, the project aims to develop a range of biological tools to make the most of the camera technologies. These combined will enable imaging of sub-microsecond events, such as calcium influx through calcium channel which signals vesicle fusion, and enable live-cell single molecule localisation microscopy of cell surface receptors, such as glucagon-like peptide 1 receptor (GLP-1R). Thus furthering our understanding of exocytosis and the role of its dysfunction in type 2 diabetes.