The Edinburgh Mouse Atlas - data-resource and analysis tool
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The Edinburgh Mouse Atlas - data-resource and analysis tool
Wed, 16/09/2015 - 14:30 to 15:30
Location:
Speaker:
Prof Richard Baldock
Affiliation:
University of Edinburgh
Synopsis:
At the MRC Human Genetics Unit we have developed the mouse embryo atlas (emouseatlas.org) to capture gene-expression data fro the developing mouse embryo. This has entailed the building of an atlas framework to capture data, allow cross-comparison and analysis of expression patterns and to generate hypotheses of gene inter rations important for embryo development. It also provides a tool for capturing anatomical knowledge and teaching. I will present the resource and how it was developed and show more recent developments in terms of spatial analysis of 3D patterns of expression.
Biography:
Some publications:
Elizabeth Graham, Julie Moss, Nick Burton, Chris Armit, Lorna Richardson and Richard Baldock (2015) The atlas of mouse development eHistology resource Development. 142:1909-1911. doi: 10.1242/dev.124917
Bill Hill and Richard A. Baldock, (2015) Constrained distance transforms for spatial atlas registration, BMC Bioinformatics 2015, 16:90, doi:10.1186/s12859-015-0504-5
Richardson L, Venkataraman S, Stevenson P, Yang Y, Moss J, Graham L, Burton N, Hill B, Rao J, Baldock RA, Armit C (2014)., EMAGE mouse embryo spatial gene expression database: (2014 update) Nucleic Acids Res. 42(1):D835-44. doi: 10.1093/nar/gkt1155
Terry F Hayamizu,Michael N Wicks, Duncan R Davidson, Albert Burger, Martin Ringwald and Richard A Baldock, EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update, Journal of Biomedical Semantics.2013, 4:15. doi:10.1186/2041-1480-4-15
Chris Armit, Shanmugasundaram Venkataraman, Lorna Richardson, Peter Stevenson, Julie Moss, Liz Graham, Allyson Ross, Yiya Yang,Nicholas Burton, Jianguo Rao, Bill Hill, Dominic Rannie, Mike Wicks, Duncan Davidson and Richard Baldock, eMouseAtlas, EMAGE, and the spatial dimension of the transcriptome, Mammalian Genome 23 (2012) 514-524 doi:10.1007/s00335-012-9407-1