Iodine Reagents in Synthesis and Flow Chemistry
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Iodine Reagents in Synthesis and Flow Chemistry
Wed, 18/01/2017 - 16:00 to 17:00
Location:
Speaker:
Prof. Thomas Wirth
Affiliation:
Cardiff University
Synopsis:
The development of catalytic reactions based on stoichiometric reactions using iodinebased
reagents will be discussed. Novel chiral reagents and catalysts allow the easy synthesis of
versatile scaffolds as synthetic building blocks as well as applications towards total synthesis.
Flow chemistry as enabling technology for synthesis will be introduced. The advantages of
increased mixing of biphasic reaction mixtures in flow offers great potential compared to
conventional flask techniques, especially when combined with microwave irradiation, sonication or
phase transfer catalysis. Metal-catalyzed sequences can also be performed advantageously in
biphasic systems. Chemistry with hazardous compounds, the synthesis of PET-tracer molecules
and the development of a microreactor for electrochemistry will be discussed.
Biography:
Thomas Wirth is professor of organic chemistry at Cardiff University. After
studying chemistry in Bonn/Germany and at the Technical University of
Berlin/Germany, he obtained his PhD in 1992 with Professor S. Blechert. After a
postdoctoral stay with Professor K. Fuji at Kyoto University a JSPS fellow, he started
his independent research at the University of Basel/Switzerland. In the group of
Professor B. Giese he obtained his habilitation on stereoselective oxidation reactions
supported by various scholarships before taking up his current position at Cardiff
University in 2000. He was invited as a visiting professor to a number of places
including the University of Toronto/Canada (1999), Chuo University in Tokyo, Osaka
University, Osaka Prefecture University and with a JSPS fellowship to Kyoto
University (2012). He was awarded the Werner-Prize from the New Swiss Chemical
Society (2000), the Furusato award from JSPS London (2013) and recently the
Wolfson Research Merit Award from the Royal Society and the Bader Award from the
Royal Society of Chemistry (2016). In 2016 he was elected as a fellow of The Learned
Society of Wales. His main interests of research concern stereoselective electrophilic
reactions, oxidative transformations with hypervalent iodine reagents including
mechanistic investigations and organic synthesis performed in microreactors.